Ivi treatment8/29/2023 ![]() Intravitreal steroids versus observation for macular edema secondary to central retinal vein occlusion. Management of macular edema due to central retinal vein occlusion – the role of aflibercept. Treasure Island, FL: StatPearls Publishing 2019. ![]() Associations of retinal artery occlusion and retinal vein occlusion to mortality, stroke, and myocardial infarction: a systematic review. No significant differences were seen between combination MLP-IVI or peripheral LPC-IVI relative to IVI monotherapy for final BCVA or OCT parameters in macular oedema secondary to RVO. Consistent results were observed when considering peripheral LPC-IVI to IVI in BRVO and CRVO. The same results were seen in subgroup analyses for macular laser without peripheral laser in BRVO and CRVO patients. Similarly, no significant differences were seen in final CMT ( p = 0.54), change in CMT ( p = 0.33), final CRT ( p = 0.90), change in CRT ( p = 0.97), or number of injections required ( p = 0.78). In comparing macular laser photocoagulation with IVI (MLP-IVI) in BRVO patients, no significant differences were seen in final BCVA ( p = 0.78) or change in BCVA ( p = 0.09) after treatment. ResultsĪ total of 10 studies were included, for which 362 eyes were randomized to LPC-IVI and 365 to IVI. The primary outcome was best-corrected visual acuity (BCVA), while secondary outcomes were central macular thickness (CMT), central retinal thickness (CRT), central subfield thickness (CST), number of IVIs received, and incidence of adverse events. Meta-analysis was conducted with a random effects model. ![]() Randomized controlled trials that reported relevant efficacy and/or safety parameters following LPC-IVI relative to IVI were included. Subjects/MethodsĪ literature search of MEDLINE, EMBASE and Cochrane CENTRAL was conducted from inception until March 2021. This meta-analysis investigates the efficacy and safety of intravitreal anti-VEGF injections (IVI) compared to combination laser photocoagulation and IVI (LPC-IVI) in treating macular oedema secondary to retinal vein occlusion (RVO).
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